Living dangerously: how Helicobacter pylori survives in the human stomach
- PMID: 11389469
- DOI: 10.1038/35073084
Living dangerously: how Helicobacter pylori survives in the human stomach
Abstract
Helicobacter pylori was already present in the stomach of primitive humans as they left Africa and spread through the world. Today, it still chronically infects more than 50% of the human population, causing, in some cases, severe diseases such as peptic ulcers and stomach cancer. To succeed in these long-term associations, H. pylori has developed a unique set of virulence factors, which allow survival in a unique and hostile ecological niche--the human stomach.
Similar articles
-
[Helicobacter pylori and gastroduodenal pathology. First Part: Pathophysiology and diagnostic methods].Gastroenterol Clin Biol. 1991;15(5):405-11. Gastroenterol Clin Biol. 1991. PMID: 2070961 Review. French. No abstract available.
-
Helicobacters and extragastric diseases.Helicobacter. 2009 Sep;14 Suppl 1:58-68. doi: 10.1111/j.1523-5378.2009.00699.x. Helicobacter. 2009. PMID: 19712170 Review.
-
[UreI: a Helicobacter pylori protein essential for resistance to acidity and for the early steps of murine gastric mucosa infection].Gastroenterol Clin Biol. 2001 Jun-Jul;25(6-7):659-63. Gastroenterol Clin Biol. 2001. PMID: 11673732 French.
-
Helicobacter pylori: consensus and controversy.Clin Infect Dis. 2002 Aug 1;35(3):298-304. doi: 10.1086/341245. Epub 2002 Jul 8. Clin Infect Dis. 2002. PMID: 12115096
-
Helicobacter pylori persistence: biology and disease.J Clin Invest. 2004 Feb;113(3):321-33. doi: 10.1172/JCI20925. J Clin Invest. 2004. PMID: 14755326 Free PMC article. Review.
Cited by
-
Association of Helicobacter pylori infection with the Lewis and ABO blood groups in dyspeptic patients.Niger Med J. 2013 May;54(3):196-9. doi: 10.4103/0300-1652.114583. Niger Med J. 2013. PMID: 23901182 Free PMC article.
-
Manipulation of rab GTPase function by intracellular bacterial pathogens.Microbiol Mol Biol Rev. 2007 Dec;71(4):636-52. doi: 10.1128/MMBR.00023-07. Microbiol Mol Biol Rev. 2007. PMID: 18063721 Free PMC article. Review.
-
Therapeutic vaccination against Helicobacter pylori in the beagle dog experimental model: safety, immunogenicity, and efficacy.Infect Immun. 2004 Jun;72(6):3252-9. doi: 10.1128/IAI.72.6.3252-3259.2004. Infect Immun. 2004. PMID: 15155627 Free PMC article.
-
Polymorphisms in the intermediate region of VacA impact Helicobacter pylori-induced disease development.J Clin Microbiol. 2011 Jan;49(1):101-10. doi: 10.1128/JCM.01782-10. Epub 2010 Nov 17. J Clin Microbiol. 2011. PMID: 21084502 Free PMC article.
-
Metallochaperone UreG serves as a new target for design of urease inhibitor: A novel strategy for development of antimicrobials.PLoS Biol. 2018 Jan 10;16(1):e2003887. doi: 10.1371/journal.pbio.2003887. eCollection 2018 Jan. PLoS Biol. 2018. PMID: 29320492 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical