doi: 10.1016/s1097-2765(01)00235-0.
Transcriptional termination factors for RNA polymerase II in yeast
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- PMID: 11389847
- DOI: 10.1016/s1097-2765(01)00235-0
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Transcriptional termination factors for RNA polymerase II in yeast
Mol Cell.
2001 May.
Free article
Abstract
The molecular connections between mRNA 3' end processing and transcriptional termination have been investigated in S. pombe using a genetic screen. By this approach, we have identified a RNAP II termination domain in the well-defined cleavage polyadenylation factor called CstF-64 in metazoans and Rna15p in S. cerevisiae. Furthermore, this C-terminal domain interacts with Res2, previously identified as a component of the G1/S transition-specific transcription factor MBF. Deletion of res2 in both fission and budding yeast results in a defect in 3' end formation. This raises the possibility that RNAP II transcriptional termination may in some situations be integrated with cell cycle events.
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