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. 1998 Feb:13:17-21.
doi: 10.1152/physiologyonline.1998.13.1.17.

Killing Mechanisms of Cytotoxic T Lymphocytes

Peter Groscurth  1 , Luis Filgueira
Affiliations

Killing Mechanisms of Cytotoxic T Lymphocytes

Peter Groscurth et al. News Physiol Sci. 1998 Feb.

Abstract

Cytotoxic T lymphocytes mediate lysis of target cells by various mechanisms, including exocytosis of lytic proteins (perforin, granzymes) and receptor-ligand binding of Fas/APO molecules. Death of target cells is characterized by either necrosis or apoptosis, depending on the killing mechanism used and on the metabolism of the target cell itself.

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