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. 1998 Aug:13:170-176.
doi: 10.1152/physiologyonline.1998.13.4.170.

Unraveling the Mystery of Goldblatt Hypertension

L. Gabriel Navar  1 , Lixian Zou, Annette Von Thun, Chi Tarng Wang, John D. Imig, Kenneth D. Mitchell
Affiliations

Unraveling the Mystery of Goldblatt Hypertension

L. Gabriel Navar et al. News Physiol Sci. 1998 Aug.

Abstract

In hypertension caused by unilateral renal artery stenosis, the nonstenotic kidney becomes renin depleted but fails to prevent hypertension. The nonstenotic kidney mysteriously develops elevated intrarenal angiotensin II (ANG II) content. Rats chronically infused with ANG II exhibit a similar hypertensive process. The augmentation of intrarenal ANG II is due to receptor-mediated internalization and continued ANG II formation, which provide a hypertensinogenic stimulus.

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