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. 1999 Oct:14:194-200.
doi: 10.1152/physiologyonline.1999.14.5.194.

Physiology of Receptor-Mediated Lymphocyte Apoptosis

F. Lang  1 , I. Szabo, A. Lepple-Wienhues, D. Siemen, E. Gulbins
Affiliations

Physiology of Receptor-Mediated Lymphocyte Apoptosis

F. Lang et al. News Physiol Sci. 1999 Oct.

Abstract

Apoptosis (programmed cell death), a physiological mechanism eliminating abundant and potentially harmful cells, is triggered by a variety of stimuli including activation of distinct receptors. The machinery mediating CD95 receptor-induced apoptosis includes caspases, ceramide, kinases, Ras and Rac, formation of O(2)(-), mitochondrial proteins, inhibition of K(+) channels, activation of Cl(-) channels, and osmolyte release.

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