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. 1999 Dec:14:271-274.
doi: 10.1152/physiologyonline.1999.14.6.271.

The Discovery of Renin 100 Years Ago

M. Ian Phillips  1 , K. M. Schmidt-Ott
Affiliations

The Discovery of Renin 100 Years Ago

M. Ian Phillips et al. News Physiol Sci. 1999 Dec.

Abstract

In 1898, Tigerstedt and Bergman published their observation that kidney extracts produce pressor effects. They characterized the substance and named it "renin." Although this was the beginning of understanding the role of the kidney in hypertension and the renin-angiotensin system, their discovery lay dormant for nearly 40 years.

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