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. 2000 Apr:15:72-77.
doi: 10.1152/physiologyonline.2000.15.2.72.

The Cell Physiology of Biphasic Insulin Secretion

Patrik Rorsman  1 , Lena Eliasson, Erik Renström, Jesper Gromada, Sebastian Barg, Sven Göpel
Affiliations

The Cell Physiology of Biphasic Insulin Secretion

Patrik Rorsman et al. News Physiol Sci. 2000 Apr.

Abstract

Glucose-stimulated insulin secretion consists of a transient first phase followed by a sustained second phase. Diabetes (type II) is associated with abnormalities in this release pattern. Here we review the evidence that biphasic insulin secretion reflects exocytosis of two functional subsets of secretory granules and the implications for diabetes.

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