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Review
. 2001 Apr:16:66-71.
doi: 10.1152/physiologyonline.2001.16.2.66.

Development of lung edema: interstitial fluid dynamics and molecular structure

G Miserocchi  1 , D Negrini, A Passi, G De Luca
Affiliations
Review

Development of lung edema: interstitial fluid dynamics and molecular structure

G Miserocchi et al. News Physiol Sci. 2001 Apr.

Abstract

Pulmonary interstitium is maintained dehydrated at subatmospheric pressure (-10 cmH(2)O) through low capillary permeability, low tissue compliance, and an efficient lymphatic drainage. Enzymatic degradation of proteoglycans disrupts the endothelial basal membrane and the matrix structure, triggering the development of pulmonary edema.

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