Hematopoietic stem cells
- PMID: 11393804
- DOI: 10.1016/s0753-3322(01)00051-8
Hematopoietic stem cells
Abstract
The adequate production of blood cells is maintained by a set of immature hematopoietic stem cells (HSC) located in the bone marrow after birth. HSC are able to reconstitute the hematopoietic system in disease-related bone marrow failure and bone marrow aplasia. Nowadays, HSC cells can be mobilized from the bone marrow into the peripheral blood using hematopoietic cytokines, allowing a convenient harvest of these cells for clinical transplantation. This review outlines the development of the hematopoietic system in the embryo and in adults and the characterization, enumeration, purification and ex vivo expansion of HSC for clinical use. Future directions include the genetic manipulation of HSC and the identification/expansion of bone marrow-derived stem cells capable of generating non-hematopoietic tissues.
Similar articles
-
Cytokine-mobilized peripheral blood CD34+Thy-1+Lin- human hematopoietic stem cells as target cells for transplantation-based gene therapy.Leukemia. 1995 Oct;9 Suppl 1:S17-25. Leukemia. 1995. PMID: 7475307
-
Long-term hematopoietic culture-initiating cells are more abundant in mobilized peripheral blood grafts than in bone marrow but have a more limited ex vivo expansion potential.Blood Cells Mol Dis. 1996;22(1):68-81. doi: 10.1006/bcmd.1996.0010. Blood Cells Mol Dis. 1996. PMID: 8807087
-
Growth factors mobilize CXCR4 low/negative primitive hematopoietic stem/progenitor cells from the bone marrow of nonhuman primates.Biol Blood Marrow Transplant. 2004 Oct;10(10):681-90. doi: 10.1016/j.bbmt.2004.07.002. Biol Blood Marrow Transplant. 2004. PMID: 15389434
-
The biology of hematopoietic stem cells.Annu Rev Cell Dev Biol. 1995;11:35-71. doi: 10.1146/annurev.cb.11.110195.000343. Annu Rev Cell Dev Biol. 1995. PMID: 8689561 Review.
-
The role of granulocyte colony-stimulating factor in mobilization and transplantation of peripheral blood progenitor and stem cells.Cytokines Mol Ther. 1995 Dec;1(4):249-70. Cytokines Mol Ther. 1995. PMID: 9384679 Review.
Cited by
-
Clinical observation of factors in the efficacy of blood component transfusion in patients following hematopoietic stem cell transplantation.PLoS One. 2012;7(5):e36912. doi: 10.1371/journal.pone.0036912. Epub 2012 May 18. PLoS One. 2012. PMID: 22701516 Free PMC article.
-
StemDriver: a knowledgebase of gene functions for hematopoietic stem cell fate determination.Nucleic Acids Res. 2024 Jan 5;52(D1):D1042-D1052. doi: 10.1093/nar/gkad1063. Nucleic Acids Res. 2024. PMID: 37953308 Free PMC article.
-
Capture and enrichment of CD34-positive haematopoietic stem and progenitor cells from blood circulation using P-selectin in an implantable device.Br J Haematol. 2008 Mar;140(6):673-81. doi: 10.1111/j.1365-2141.2007.06967.x. Epub 2008 Jan 22. Br J Haematol. 2008. PMID: 18218048 Free PMC article.
-
Stem cell-based cell therapy for glomerulonephritis.Biomed Res Int. 2014;2014:124730. doi: 10.1155/2014/124730. Epub 2014 Jun 9. Biomed Res Int. 2014. PMID: 25003105 Free PMC article. Review.
-
Chronic benzene exposure impairs the self-renewal capacity of HSPCs in C57BL/6 mice.Toxicol Res (Camb). 2025 Feb 17;14(1):tfaf021. doi: 10.1093/toxres/tfaf021. eCollection 2025 Feb. Toxicol Res (Camb). 2025. PMID: 39968519
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
