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. 1975 Mar;4(3):113-20.
doi: 10.1016/0010-468x(75)90013-6.

Interactive simulator for pharmacokinetics of repetitive drug dosing

G A Iben, J H Anderson

Interactive simulator for pharmacokinetics of repetitive drug dosing

G A Iben et al. Comput Programs Biomed. 1975 Mar.

Abstract

DRUGSIM is a highly interactive program allowing simulation of the effects of repeated drug administration by a variety of routes on plasma concentrations of drugs over a period of time. Drug parameters are read from a data file; prescriptions are obtained from the user at various points during run time. The results for one or two compartment pharmacokinetics are plotted on a storage display tube, and the user is queried for further prescriptions. Simulation involves a point-slope method with a variable time step. The program is written in Fortran IV and run on a DEC PDP-10 computer using a Computek 611 display terminal.

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