Review
doi: 10.1016/s0959-4388(00)00214-2.
How does calcium trigger neurotransmitter release?
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- PMID: 11399430
- DOI: 10.1016/s0959-4388(00)00214-2
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Review
How does calcium trigger neurotransmitter release?
Curr Opin Neurobiol.
2001 Jun.
Abstract
Recent work has established that different geometric arrangements of calcium channels are found at different presynaptic terminals, leading to a wide spectrum of calcium signals for triggering neurotransmitter release. These calcium signals are apparently transduced by synaptotagmins - calcium-binding proteins found in synaptic vesicles. New biochemical results indicate that all synaptotagmins undergo calcium-dependent interactions with membrane lipids and a number of other presynaptic proteins, but which of these interactions is responsible for calcium-triggered transmitter release remains unclear.
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