Review
doi: 10.1016/s0959-4388(00)00217-8.
NMDA receptor-mediated dendritic spikes and coincident signal amplification
Affiliations
- PMID: 11399433
- DOI: 10.1016/s0959-4388(00)00217-8
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Review
NMDA receptor-mediated dendritic spikes and coincident signal amplification
Curr Opin Neurobiol.
2001 Jun.
Abstract
Dendrites of cortical neurons possess active conductances, which contribute to the nonlinear processing of synaptic information. Recently it has been shown that basal dendrites can generate highly localized spikes mediated by NMDA receptor channels. These spikes may serve as a powerful mechanism to detect and amplify synchronously activated spatially clustered excitatory synaptic inputs in individual dendritic segments, and may enable parallel processing in several integrative dendritic subunits.
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