Review
doi: 10.1016/s0959-4388(00)00219-1.
Coordinate regulation of metabotropic glutamate receptors
Affiliations
- PMID: 11399435
- DOI: 10.1016/s0959-4388(00)00219-1
Item in Clipboard
Review
Coordinate regulation of metabotropic glutamate receptors
Curr Opin Neurobiol.
2001 Jun.
Abstract
Recent studies aimed at identifying the mechanisms that regulate the signaling of metabotropic glutamate receptors (mGluRs) have revealed that both protein kinase and protein phosphatase activity are important in directly modulating mGluR function. The inter-relationship between phosphorylation and dephosphorylation of mGluRs seems to be an important determinant in regulating mGluR function and the subsequent neuromodulatory events elicited by activation of mGluRs.
Similar articles
-
Metabotropic glutamate receptor modulation of glutamate responses in the suprachiasmatic nucleus.J Neurophysiol. 1999 Mar;81(3):1308-17. doi: 10.1152/jn.1999.81.3.1308. J Neurophysiol. 1999. PMID: 10085357
-
Group II metabotropic glutamate receptors enhance NMDA receptor currents via a protein kinase C-dependent mechanism in pyramidal neurones of rat prefrontal cortex.J Physiol. 2004 Feb 1;554(Pt 3):765-77. doi: 10.1113/jphysiol.2003.056812. Epub 2003 Nov 28. J Physiol. 2004. PMID: 14645456 Free PMC article.
-
Functional interactions between presynaptic NMDA receptors and metabotropic glutamate receptors co-expressed on rat and human noradrenergic terminals.Br J Pharmacol. 2007 Aug;151(7):1087-94. doi: 10.1038/sj.bjp.0707280. Epub 2007 Jun 25. Br J Pharmacol. 2007. PMID: 17592518 Free PMC article.
-
Novel functions for subtypes of metabotropic glutamate receptors.Neurochem Int. 1994 May;24(5):439-49. doi: 10.1016/0197-0186(94)90092-2. Neurochem Int. 1994. PMID: 7647699 Review.
-
Metabotropic glutamate receptors: electrical and chemical signaling properties.Neuroscientist. 2002 Dec;8(6):551-61. doi: 10.1177/1073858402238514. Neuroscientist. 2002. PMID: 12467377 Review.
Cited by
-
M1 muscarinic acetylcholine receptor dysfunction in moderate Alzheimer's disease pathology.Brain Commun. 2020;2(2):fcaa058. doi: 10.1093/braincomms/fcaa058. Epub 2020 May 12. Brain Commun. 2020. PMID: 32766549 Free PMC article.
-
Protein phosphatase 2C binds selectively to and dephosphorylates metabotropic glutamate receptor 3.Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):16006-11. doi: 10.1073/pnas.2136600100. Epub 2003 Dec 8. Proc Natl Acad Sci U S A. 2003. PMID: 14663150 Free PMC article.
-
Molecular diffusion model of neurotransmitter homeostasis around synapses supporting gradients.Neural Comput. 2011 Apr;23(4):984-1014. doi: 10.1162/NECO_a_00101. Epub 2011 Jan 11. Neural Comput. 2011. PMID: 21222526 Free PMC article.
-
The group I metabotropic glutamate receptor mGluR5 is required for fear memory formation and long-term potentiation in the lateral amygdala.J Neurosci. 2002 Jun 15;22(12):5219-29. doi: 10.1523/JNEUROSCI.22-12-05219.2002. J Neurosci. 2002. PMID: 12077217 Free PMC article.
-
The role of water and protein flexibility in the structure-based virtual screening of allosteric GPCR modulators: an mGlu5 receptor case study.J Comput Aided Mol Des. 2019 Sep;33(9):787-797. doi: 10.1007/s10822-019-00224-w. Epub 2019 Sep 21. J Comput Aided Mol Des. 2019. PMID: 31542869 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
