doi: 10.1054/bjoc.2001.1830.
Proteolysis-inducing factor is expressed in tumours of patients with gastrointestinal cancers and correlates with weight loss
Affiliations
- PMID: 11401311
- PMCID: PMC2363676
- DOI: 10.1054/bjoc.2001.1830
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Proteolysis-inducing factor is expressed in tumours of patients with gastrointestinal cancers and correlates with weight loss
Br J Cancer.
.
Free PMC article
Abstract
Proteolysis-inducing factor (PIF), a novel cachectic factor, is detectable in the urine of cancer patients experiencing weight loss. We report the expression of PIF in gastrointestinal cancers, and a correlation between PIF expression in tumours, its detection in urine and weight-loss. These data provide the first direct evidence that tumours are the source of PIF in humans.
Copyright 2001 Cancer Research Campaign.
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