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. 2001 Jun;18(3):169-72.

[Study of susceptibility loci located within Xp11 in attention deficit hyperactivity disorder]

[Article in Chinese]
S Jiang  1 , R Xin, Y Qian, S Lin, F Li, X Wu, D Wang, G Tang, K Jiang
Affiliations
  • PMID: 11402442

[Study of susceptibility loci located within Xp11 in attention deficit hyperactivity disorder]

[Article in Chinese]
S Jiang et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2001 Jun.

Abstract

Objective: To detect the genetic relationship between monoamine oxidase(MAO) A type gene and attention deficit hyperactivity disorder(ADHD) in Chinese.

Methods: The haplotype-based haplotype relative risk(HHRR) and the transmission disequilibrium test(TDT) methods were used to analyze the genetic association and linkage in 60 ADHD children and their parents.

Results: In this sample were found significant association (chi(2)=4.90, P<0.05) and linkage (chi(2)=4.84, P<0.05) between the MAOCA 114bp allele and DSM-III-R-diagnosed ADHD in trios composed of father, mother and affected offspring.

Conclusion: The above results suggested that ADHD was associated and in linkage with MAO A gene, and the susceptibility loci might reside in chromosome Xp11 for ADHD.

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