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. 2001 Jun 22;306(1-2):89-92.
doi: 10.1016/s0304-3940(01)01885-7.

SHIRPA, a protocol for behavioral assessment: validation for longitudinal study of neurological dysfunction in mice

D C Rogers  1 , J Peters, J E Martin, S Ball, S J Nicholson, A S Witherden, M Hafezparast, J Latcham, T L Robinson, C A Quilter, E M Fisher
Affiliations

SHIRPA, a protocol for behavioral assessment: validation for longitudinal study of neurological dysfunction in mice

D C Rogers et al. Neurosci Lett. .

Abstract

Mouse models of neurological abnormalities are only valuable if accurately assessed. The three-stage SHIRPA procedure is used for the standardised assessment of mouse phenotype and has been reported in a high throughput experiment in which different mutants were ascertained at one age point using stage 1 of the protocol. In this study we have validated SHIRPA using a large cohort with one single mutation, 'legs at odd angles that causes neurological dysfunction. The cohort aged from 1 to 16 months during this study and this is the first longitudinal SHIRPA analysis.

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