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Review
. 2001 Jun;11(3):293-301.
doi: 10.1016/s0959-440x(00)00205-0.

DNA-cation interactions: The major and minor grooves are flexible ionophores

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Review

DNA-cation interactions: The major and minor grooves are flexible ionophores

N V Hud et al. Curr Opin Struct Biol. 2001 Jun.

Abstract

Several crystallographic, solution-state and theoretical studies carried out this past year provide new support for the sequence-specific nature of monovalent and divalent cation coordination within the DNA major and minor grooves. Correlations observed between groove width and cation coordination indicate that the grooves are flexible and respond to cation binding.

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