Review
doi: 10.1016/s0968-0004(01)01827-8.
RNA editing by base deamination: more enzymes, more targets, new mysteries
Affiliations
- PMID: 11406411
- DOI: 10.1016/s0968-0004(01)01827-8
Item in Clipboard
Review
RNA editing by base deamination: more enzymes, more targets, new mysteries
Trends Biochem Sci.
2001 Jun.
Abstract
The posttranscriptional modification of messenger RNA precursors (pre-mRNAs) by base deamination can profoundly alter the physiological function of the encoded proteins. The recent identification of tRNA-specific adenosine deaminases (ADATs) has led to the suggestion that these enzymes, as well as the cytidine and adenosine deaminases acting on pre-mRNAs (CDARs and ADARs), belong to a superfamily of RNA-dependent deaminases. This superfamily might have evolved from an ancient cytidine deaminase. This article reviews the reactions catalysed by these enzymes and discusses their evolutionary relationships.
Similar articles
-
RNA editing by adenosine deaminases generates RNA and protein diversity.Biochimie. 2002 Aug;84(8):791-803. doi: 10.1016/s0300-9084(02)01446-3. Biochimie. 2002. PMID: 12457566 Review.
-
An adenosine-to-inosine tRNA-editing enzyme that can perform C-to-U deamination of DNA.Proc Natl Acad Sci U S A. 2007 May 8;104(19):7821-6. doi: 10.1073/pnas.0702394104. Epub 2007 May 1. Proc Natl Acad Sci U S A. 2007. PMID: 17483465 Free PMC article.
-
Diverse functions for DNA and RNA editing in the immune system.RNA Biol. 2010 Mar-Apr;7(2):220-8. doi: 10.4161/rna.7.2.11344. Epub 2010 Mar 29. RNA Biol. 2010. PMID: 20220309 Review.
-
The properties of a tRNA-specific adenosine deaminase from Drosophila melanogaster support an evolutionary link between pre-mRNA editing and tRNA modification.Mol Cell Biol. 2000 Feb;20(3):825-33. doi: 10.1128/MCB.20.3.825-833.2000. Mol Cell Biol. 2000. PMID: 10629039 Free PMC article.
-
An adenosine deaminase that generates inosine at the wobble position of tRNAs.Science. 1999 Nov 5;286(5442):1146-9. doi: 10.1126/science.286.5442.1146. Science. 1999. PMID: 10550050
Cited by
-
Precision genome editing in the eye.Proc Natl Acad Sci U S A. 2022 Sep 27;119(39):e2210104119. doi: 10.1073/pnas.2210104119. Epub 2022 Sep 19. Proc Natl Acad Sci U S A. 2022. PMID: 36122230 Free PMC article.
-
The ADAR protein family.Genome Biol. 2012 Dec 28;13(12):252. doi: 10.1186/gb-2012-13-12-252. Genome Biol. 2012. PMID: 23273215 Free PMC article. Review.
-
C-to-U RNA Editing: A Site Directed RNA Editing Tool for Restoration of Genetic Code.Genes (Basel). 2022 Sep 12;13(9):1636. doi: 10.3390/genes13091636. Genes (Basel). 2022. PMID: 36140804 Free PMC article. Review.
-
tadA, an essential tRNA-specific adenosine deaminase from Escherichia coli.EMBO J. 2002 Jul 15;21(14):3841-51. doi: 10.1093/emboj/cdf362. EMBO J. 2002. PMID: 12110595 Free PMC article.
-
Underediting of glutamate receptor GluR-B mRNA in malignant gliomas.Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14687-92. doi: 10.1073/pnas.251531398. Epub 2001 Nov 20. Proc Natl Acad Sci U S A. 2001. PMID: 11717408 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
