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. 2001 May;68(5):417-9.
doi: 10.1007/BF02723017.

Neuronal protection with magnesium

G Gathwala  1
Affiliations

Neuronal protection with magnesium

G Gathwala. Indian J Pediatr. 2001 May.

Abstract

Delayed neuronal death following hypoxic ischaemic insult is primarily mediated by the N-methyl D-aspartate (NMDA) receptor. The NMDA receptor antagonist MK 801, has been shown to limit neuronal death following hypoxic ischaemic injury but is too toxic to be used in the human neonate. Magnesium blocks the NMDA channel in a voltage dependent manner. Its administration after a simulated hypoxic ischaemic insult limits neurological damage in several animal models. The efficacy of magnesium in providing neuroprotection in the human neonate, however needs to be established in controlled clinical trials.

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References

    1. Arch Dis Child. 1992 Jan;67(1 Spec No):31-5 - PubMed
    1. Pediatr Res. 1997 Jun;41(6):809-14 - PubMed
    1. Exp Neurol. 1989 Dec;106(3):289-96 - PubMed
    1. Brain Res. 1989 Mar 20;482(2):252-60 - PubMed
    1. Arch Dis Child Fetal Neonatal Ed. 1995 Nov;73(3):F174-7 - PubMed