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. 2001 Jul;45(7):2136-40.
doi: 10.1128/AAC.45.7.2136-2140.2001.

Fluoroquinolone resistance in anaerobic bacteria following exposure to levofloxacin, trovafloxacin, and sparfloxacin in an in vitro pharmacodynamic model

G H Ross  1 , D H Wright, L B Hovde, M L Peterson, J C Rotschafer
Affiliations

Fluoroquinolone resistance in anaerobic bacteria following exposure to levofloxacin, trovafloxacin, and sparfloxacin in an in vitro pharmacodynamic model

G H Ross et al. Antimicrob Agents Chemother. 2001 Jul.

Abstract

This investigation explored pharmacodynamic characteristics of fluoroquinolones against Bacteroides thetaiotamicron and the potential for development of resistance. An in vitro model was used to generate kill curves with three fluoroquinolones at various area under the concentration-time curve (AUC)/MIC ratios. Concentration-independent killing was observed. Increases in MICs were noted following exposure to fluoroquinolones at AUC/MIC ratios of 6 to 14.

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Figures

FIG. 1
FIG. 1
Activity of levofloxacin at AUC/MIC ratios of 1 (✻), 6 (●), 14 (⧫), 75 (■), and 293 (⧫) (A); activity of sparfloxacin at AUC/MIC ratios of 1 (✻), 4 (●), 12 (⧫), 53 (■), and 143 (⧫) (B); and activity of trovafloxacin at AUC/MIC ratios of 1 (✻), 4 (●), 11 (⧫), 56 (■), and 138 (⧫) (C) against B. thetaiotamicron 29741. Growth controls are represented by (×).
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