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. 2001 Jul;45(7):2173-6.
doi: 10.1128/AAC.45.7.2173-2176.2001.

Domestic cat model for predicting human nucleoside analogue pharmacokinetics in blood and seminal plasma

H L Jordan  1 , A S Pereira, M S Cohen, A D Kashuba
Affiliations

Domestic cat model for predicting human nucleoside analogue pharmacokinetics in blood and seminal plasma

H L Jordan et al. Antimicrob Agents Chemother. 2001 Jul.

Abstract

To establish whether a feline model can predict nucleoside analogue behavior in human semen, zidovudine (ZDV) and lamivudine (3TC) pharmacokinetic parameters (PKs) were determined in the blood and seminal plasma of healthy cats. Our results show considerable similarity in ZDV and 3TC PKs between cats and humans. As in humans, ZDV and 3TC tend to accumulate in feline seminal plasma. Area under the blood plasma concentration-time curve was predictive of seminal plasma excretion. The felid model offers a unique in vivo experimental alternative for investigating the pharmacokinetics of nucleoside analogues in the male genital tract.

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Figures

FIG. 1
FIG. 1
Trough concentrations (C12, in nanograms per milliliter) of ZDV and 3TC in seminal plasma from domestic cats after first dose (day 1) and at steady state (day 7).
FIG. 2
FIG. 2
The excretion (seminal plasma volume times trough drug concentration, in nanograms) of ZDV and 3TC in ejaculates from domestic cats after first dose and steady state.
FIG. 3
FIG. 3
Log graph of trough concentrations (C12, in nanograms per milliliter) of ZDV (open symbols) and 3TC (solid symbols) in feline seminal plasma with increasing time between semen collection. Semen was collected from all cats during day 1 and day 7; semen was also collected from cat 1 during day 5.
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