Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2001 Jul;60(1):75-9.
doi: 10.1016/s0167-8140(01)00370-x.

Normal cellular radiosensitivity in an adult Fanconi anaemia patient with marked clinical radiosensitivity

Y Marcou  1 , A D'Andrea, P A Jeggo, P N Plowman
Affiliations
Case Reports

Normal cellular radiosensitivity in an adult Fanconi anaemia patient with marked clinical radiosensitivity

Y Marcou et al. Radiother Oncol. 2001 Jul.

Abstract

Background: Fanconi anaemia is a rare disease associated with cellular sensitivity to chemicals (e.g. mitomycin C and diepoxybutane); variable but mild cellular radiosensitivity has also been reported.

Materials and methods: A 32-year-old patient with Fanconi anaemia and tonsillar carcinoma, treated by radiotherapy, was found to exhibit profound clinical radiosensitivity. Confluent, ulcerating oropharyngeal mucositis developed after a conventionally fractionated dose of 34Gy and healing was incomplete by 2 months after cessation of therapy.

Results: Cellular radiosensitivity assays and RPLD studies from this patient did not suggest any major detectable radiosensitivity.

Conclusion: There is a discrepancy between the observed clinical radiosensitivity and the usual "predictive" radiosensitivity assays in this patient with Fanconi anaemia.

PubMed Disclaimer

Comment in

Publication types

LinkOut - more resources