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Comment
. 2001 Jun;107(12):1497-8.
doi: 10.1172/JCI13259.

Acute graft-versus-host disease: inflammation run amok?

J H Antin  1
Affiliations
Comment

Acute graft-versus-host disease: inflammation run amok?

J H Antin. J Clin Invest. 2001 Jun.
No abstract available

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Figures

Figure 1
Figure 1
Pathophysiology of GVHD. Injury to host epithelia and endothelium generates injury signals that recruit donor T cells. In this inflammatory milieu, the donor T cells recognize minor histocompatibility antigens, resulting in activation and proliferation. The T cells then cause further injury through both specific and nonspecific mechanisms. This process is amplified by endotoxin. The clinical manifestations of this process are seen in GVHD. PMN, polymorphonuclear leukocyte; NK, natural killer.
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References

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