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Review
. 2001 Jan;2(1):67-71.
doi: 10.1038/35048073.

The mitochondrion in apoptosis: how Pandora's box opens

N Zamzami  1 , G Kroemer
Affiliations
Review

The mitochondrion in apoptosis: how Pandora's box opens

N Zamzami et al. Nat Rev Mol Cell Biol. 2001 Jan.

Abstract

There is widespread agreement that mitochondria have a function in apoptosis, but the mechanisms behind their involvement remain controversial. Here we suggest that opening of a multiprotein complex called the mitochondrial permeability transition pore complex is sufficient (and, usually, necessary) for triggering apoptosis.

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