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. 1975 Feb 19;105(1):107-13.
doi: 10.1016/s0021-9673(01)81094-3.

Sensitive method for the routine determination tricyclic antidepressants in plasma using a specific nitrogen detector

L A Gifford, P Turner, C M Pare

Sensitive method for the routine determination tricyclic antidepressants in plasma using a specific nitrogen detector

L A Gifford et al. J Chromatogr. .

Abstract

The sensitivity of the alkali flame ionization detector to the tricyclic antidepressant drugs has been studied and limits of detection measured. A backflush system has been used to enable measurement in plasma extracts. A general method for the estimation of tricyclic plasma levels has been developed and exemplified by the measurement of imipramine at therapeutic levels.

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