[Prognostication of obstructive syndrome in patients with chronic bronchitis considering hereditary factors]

Abstract

Aim: To propose method of accurate prediction of chronic obstructive pulmonary disease (COPD) at early stages of development.

Material and methods: 92 males with COPD and 55 males with chronic non-obstructive bronchitis aged 38 to 72 years were examined according to a technique which identifies hereditary predisposition to multifactor diseases and using an algorithm based on multivariate analysis.

Results: An original mathematical model is proposed which can quantitatively examine and range by influence the role of environmental and hereditary factors in development of COPD.

Conclusion: Detection of hereditary predisposition to COPD may be one of the objective criteria to recommend giving up smoking and for occupational orientation.