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. 2001 Jun 28;3(13):2049-51.
doi: 10.1021/ol0160147.

Reactive ketenes through a carbonate/amine shuttle deprotonation strategy: catalytic, enantioselective alpha-bromination of acid chlorides

A M Hafez  1 , A E Taggi, H Wack, J Esterbrook, T Lectka
Affiliations

Reactive ketenes through a carbonate/amine shuttle deprotonation strategy: catalytic, enantioselective alpha-bromination of acid chlorides

A M Hafez et al. Org Lett. .

Abstract

[reaction: see text] We have developed an efficient methodology for the generation of ketenes by employing a catalytic shuttle base and potassium carbonate as a stoichiometric base. We have applied this technology to the catalytic, asymmetric alpha-bromination of acid chlorides.

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