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. 2001 Jul;48(1):105-7.
doi: 10.1093/jac/48.1.105.

In vitro effects of photodynamic therapy on Aspergillus fumigatus

J S Friedberg  1 , C Skema, E D Baum, J Burdick, S A Vinogradov, D F Wilson, A D Horan, I Nachamkin
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In vitro effects of photodynamic therapy on Aspergillus fumigatus

J S Friedberg et al. J Antimicrob Chemother. 2001 Jul.

Abstract

Photodynamic therapy is a technique for killing cells with visible light after pretreatment with a photosensitizing agent. We demonstrated significant in vitro fungicidal activity against Aspergillus fumigatus of the photosensitizer Green 2W, activated with 630 nm light. This effect was both inoculum- and light dose-dependent. At a Green 2W concentration of 31.5 mg/L, there was complete killing of 2.7 x 10(1) cfu/mL with a light dose of 110 J/cm(2) and up to 2.7 x 10(6) cfu/mL with a light dose of 385 J/cm(2).

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