Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2001 Jul;85(1):23-5.
doi: 10.1136/adc.85.1.23.

Total serum IgE and outcome in infants with recurrent wheezing

F Rusconi  1 , M F Patria, G U Cislaghi, S Sideri, L Gagliardi
Affiliations

Total serum IgE and outcome in infants with recurrent wheezing

F Rusconi et al. Arch Dis Child. 2001 Jul.

Abstract

Objective: To investigate the relation between total serum IgE at 0.5-3 and 3-6 years, and the risk of allergic sensitisation and persistent wheezing up to 8 years of age.

Methods: Prospective follow up study of 45 infants with highly recurrent wheezing, no allergic symptoms, and negative skin tests.

Results: In the last follow up year, 15 children still suffered from wheezing. Five wheeze-free and four episodically wheezing children had become sensitised. No association was found between early (0.5-3 years) IgE z scores and the recurrence of wheezing during follow up, or atopic sensitisation. IgE z scores at 3-6 years were significantly higher in children with positive skin tests (p = 0.013), but were still not associated with recurrence of wheezing.

Conclusions: In subjects with frequent early wheezing and no signs of atopy, early total serum IgE measurements are not predictive of outcome.

PubMed Disclaimer

References

    1. Br Med J. 1969 Nov 8;4(5679):321-5 - PubMed
    1. Arch Dis Child. 1995 Apr;72(4):317-20 - PubMed
    1. J Allergy Clin Immunol. 1979 Aug;64(2):127-30 - PubMed
    1. Br Med J (Clin Res Ed). 1983 Apr 16;286(6373):1253-6 - PubMed
    1. Am J Respir Crit Care Med. 1995 Nov;152(5 Pt 1):1497-500 - PubMed