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Review
. 2001 Jun 23;322(7301):1536-8.
doi: 10.1136/bmj.322.7301.1536.

What is apoptosis, and why is it important?

A G Renehan  1 , C Booth, C S Potten
Affiliations
Review

What is apoptosis, and why is it important?

A G Renehan et al. BMJ. .
No abstract available

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Figures

Figure
Figure
Apoptotic mechanisms in a human cell. Three major pathways are shown, indicating the main levels: death signals, gene regulation, and effector mechanisms. BH3 and bcl-2 represent the pro-apoptotic and anti-apoptotic members of the bcl-2 family. Apaf-1=apoptosis proteases activating factor
See this image and copyright information in PMC

Comment in

  • Why is apoptosis important to clinicians?
    Haslett C, Savill J. Haslett C, et al. BMJ. 2001 Jun 23;322(7301):1499-500. doi: 10.1136/bmj.322.7301.1499. BMJ. 2001. PMID: 11420256 Free PMC article. No abstract available.

References

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    1. Renehan AG, Bach SP, Potten SC. The relevance of apoptosis for cellular homeostasis and tumorogenesis in the intestine. Can J Gastroenterol. 20001;15:1666–1676. - PubMed
    1. Potten CS. What is an apoptotic index measuring? A commentary. Br J Cancer. 1996;74:1743–1748. - PMC - PubMed
    1. Norimura T, Nomoto S, Katsuki M, Gondo Y, Kondo S. p53-dependent apoptosis suppresses radiation-induced teratogenesis. Nat Med. 1996;2:577–580. - PubMed