Review
doi: 10.1016/s0923-2508(01)01208-6.
Multidrug transport by ATP binding cassette transporters: a proposed two-cylinder engine mechanism
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- PMID: 11421284
- DOI: 10.1016/s0923-2508(01)01208-6
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Review
Multidrug transport by ATP binding cassette transporters: a proposed two-cylinder engine mechanism
Res Microbiol.
2001 Apr-May.
Free article
Abstract
The elevated expression of ATP binding cassette (ABC) multidrug transporters in multidrug-resistant cells interferes with the drug-based control of cancers and infectious pathogenic microorganisms. Multidrug transporters interact directly with the drug substrates. This review summarizes current insights into the mechanism(s) by which ATP hydrolysis is coupled to drug transport in bacterial LmrA and its human homolog P-glycoprotein. In addition, the relevance of these insights for other ABC transporters will be discussed.
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