Review
doi: 10.1016/s0923-2508(01)01210-4.
Translational regulation by ABC systems
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- PMID: 11421286
- DOI: 10.1016/s0923-2508(01)01210-4
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Review
Translational regulation by ABC systems
Res Microbiol.
2001 Apr-May.
Free article
Abstract
Elongation factor 3 is a cytosolic protein required by the fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates binding of EF-1:GTP:aa-tRNA ternary complex to the ribosomal A site by facilitated release of the deacylated tRNA from the E site. The reaction requires ATP hydrolysis. EF-3 contains two ATP binding sequence (NBS) motifs. NBSI is sufficient for the intrinsic ATPase activity. NBSII is essential for the ribosome-stimulated functions.
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