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Review
. 2001 Apr-May;152(3-4):401-9.
doi: 10.1016/s0923-2508(01)01211-6.

Role of ATP hydrolysis by UvrA and UvrB during nucleotide excision repair

N Goosen  1 , G F Moolenaar
Affiliations
Free article
Review

Role of ATP hydrolysis by UvrA and UvrB during nucleotide excision repair

N Goosen et al. Res Microbiol. 2001 Apr-May.
Free article

Abstract

Nucleotide excision repair in eubacteria is a process that repairs DNA damages by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep ATP-dependent reaction that requires the UvrA, UvrB and UvrC proteins. Both UvrA and UvrB are ATPases, with UvrA having two ATP binding sites which have the characteristic signature of the family of ABC proteins and UvrB having one ATP binding site that is structurally related to that of helicases.

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