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. 2001 Jun 29;905(1-2):220-3.
doi: 10.1016/s0006-8993(01)02484-2.

Reduction of cerebrospinal fluid amyloid beta after systemic administration of M1 muscarinic agonists

T G Beach  1 , D G Walker, P E Potter, L I Sue, A Fisher
Affiliations

Reduction of cerebrospinal fluid amyloid beta after systemic administration of M1 muscarinic agonists

T G Beach et al. Brain Res. .

Abstract

Overproduction of the peptide amyloid beta (A beta) is a critical event in Alzheimer's disease (AD). Systemic administration of 3 M1-selective muscarinic agonists, AF102B, AF150S and AF267B, decreased cerebrospinal fluid (CSF) A beta concentrations; levels of CSF secreted beta-APP were not significantly altered. Rabbits treated for 5 days with s.c. injections of each drug (2 mg/kg/day) had levels of CSF A beta which were between 55 and 71% of control for A beta 1-40 and between 59 and 84% of control for A beta 1--42.

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