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Review
. 2001 Jul;22(7):356-60.
doi: 10.1016/s1471-4906(01)01964-0.

Oligomeric antigen receptors: a new view on signaling for the selection of lymphocytes

M Reth  1
Affiliations
Review

Oligomeric antigen receptors: a new view on signaling for the selection of lymphocytes

M Reth. Trends Immunol. 2001 Jul.

Abstract

Antigen receptors on lymphocytes utilize different signaling modes to control the positive and negative selection of lymphocytes. In addition, these receptors have to detect the amount and affinity of the antigen and set delicate threshold values for the activation of lymphocytes. It is suggested that the antigen receptors on B and T-cells form oligomeric complexes, inside of which, signals can be processed and amplified in a manner that might explain the different signaling outputs of these receptors.

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Comment in

  • TCR: losing its inhibitions?
    Cameron TO, Stone JD, Cochran JR, Stern LJ. Cameron TO, et al. Trends Immunol. 2001 Sep;22(9):479-80. doi: 10.1016/s1471-4906(01)01996-2. Trends Immunol. 2001. PMID: 11556322 No abstract available.
  • Antigen recognition by T cells: a strong sense of structure.
    Maeurer M, Höhn H, Castelli C, Salter RD, Necker A, Reichert T, Knuth A, Jäger E. Maeurer M, et al. Trends Immunol. 2001 Nov;22(11):599-601. doi: 10.1016/s1471-4906(01)02061-0. Trends Immunol. 2001. PMID: 11698218 No abstract available.

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