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Comment

. 2001 Jul;2(7):573-4.

doi: 10.1038/89709.

ICOS costimulation: It's not just for TH2 cells anymore

A I Sperling¹, J A Bluestone

Affiliations

Affiliation

¹ Section of Pulmonary and Critical Care Medicine, Department of Medicine, and the Committee on Immunology, University of Chicago, Chicago, IL 60637, USA. asperlin@medicine.bsd.uchicago.edu

PMID: 11429535
DOI: 10.1038/89709

Comment

ICOS costimulation: It's not just for TH2 cells anymore

A I Sperling et al. Nat Immunol. 2001 Jul.

. 2001 Jul;2(7):573-4.

doi: 10.1038/89709.

Authors

A I Sperling¹, J A Bluestone

Affiliation

¹ Section of Pulmonary and Critical Care Medicine, Department of Medicine, and the Committee on Immunology, University of Chicago, Chicago, IL 60637, USA. asperlin@medicine.bsd.uchicago.edu

PMID: 11429535
DOI: 10.1038/89709

Abstract

A current paradigm has ICOS participating in TH2 costimulation. New data indicates ICOS regulates not only TH2 cells, but also TH1s.

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Comment on

Importance of ICOS-B7RP-1 costimulation in acute and chronic allograft rejection.
Ozkaynak E, Gao W, Shemmeri N, Wang C, Gutierrez-Ramos JC, Amaral J, Qin S, Rottman JB, Coyle AJ, Hancock WW. Ozkaynak E, et al. Nat Immunol. 2001 Jul;2(7):591-6. doi: 10.1038/89731. Nat Immunol. 2001. PMID: 11429542
ICOS is critical for T helper cell-mediated lung mucosal inflammatory responses.
Gonzalo JA, Tian J, Delaney T, Corcoran J, Rottman JB, Lora J, Al-garawi A, Kroczek R, Gutierrez-Ramos JC, Coyle AJ. Gonzalo JA, et al. Nat Immunol. 2001 Jul;2(7):597-604. doi: 10.1038/89739. Nat Immunol. 2001. PMID: 11429543
The costimulatory molecule ICOS plays an important role in the immunopathogenesis of EAE.
Rottman JB, Smith T, Tonra JR, Ganley K, Bloom T, Silva R, Pierce B, Gutierrez-Ramos JC, Ozkaynak E, Coyle AJ. Rottman JB, et al. Nat Immunol. 2001 Jul;2(7):605-11. doi: 10.1038/89750. Nat Immunol. 2001. PMID: 11429544

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