doi: 10.1021/np000372l.
A novel anti-HIV macrocyclic peptide from Palicourea condensata
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- PMID: 11430013
- DOI: 10.1021/np000372l
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A novel anti-HIV macrocyclic peptide from Palicourea condensata
J Nat Prod.
2001 Feb.
Abstract
A 37 amino acid cyclic polypeptide has been isolated from the organic extract of the tropical tree Palicourea condensata. Palicourein (1) is the largest of a growing family of plant peptides that contain a cyclized amino acid backbone cross-linked via three internal disulfide bridges. Palicourein inhibits the in vitro cytopathic effects of HIV-1RF infection of CEM-SS cells with an EC50 value of 0.1 microM and an IC50 value of 1.5 microM.
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