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. 2001 Feb;64(2):249-50.
doi: 10.1021/np000372l.

A novel anti-HIV macrocyclic peptide from Palicourea condensata

H R Bokesch  1 , L K Pannell, P K Cochran, R C Sowder 2nd, T C McKee, M R Boyd
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A novel anti-HIV macrocyclic peptide from Palicourea condensata

H R Bokesch et al. J Nat Prod. 2001 Feb.

Abstract

A 37 amino acid cyclic polypeptide has been isolated from the organic extract of the tropical tree Palicourea condensata. Palicourein (1) is the largest of a growing family of plant peptides that contain a cyclized amino acid backbone cross-linked via three internal disulfide bridges. Palicourein inhibits the in vitro cytopathic effects of HIV-1RF infection of CEM-SS cells with an EC50 value of 0.1 microM and an IC50 value of 1.5 microM.

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