Review
doi: 10.1016/s0165-6147(00)01713-2.
Towards a pharmacology of DNA methylation
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- PMID: 11431029
- DOI: 10.1016/s0165-6147(00)01713-2
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Review
Towards a pharmacology of DNA methylation
Trends Pharmacol Sci.
2001 Jul.
Abstract
DNA methylation plays an important role in controlling gene-expression programs. Increasing evidence indicates that the enzyme responsible for replicating the DNA methylation pattern, DNA methyltransferase 1 (DNMT1), has a role in cancer. In this article, it is suggested that DNMT1 is a multifunctional protein that has regulatory activities in addition to DNA methylation activity. These functions are assembled into one protein to ensure the coordinate replication of DNA and its methylation pattern. The regulatory activities of DNMT1 are proposed to be involved in cellular transformation and should, therefore, serve as the targets for novel anti-cancer agents.
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