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. 2001 Jun 29;292(5526):2501-4.
doi: 10.1126/science.1059365.

Conditional restoration of hippocampal synaptic potentiation in Glur-A-deficient mice

V Mack  1 , N Burnashev, K M Kaiser, A Rozov, V Jensen, O Hvalby, P H Seeburg, B Sakmann, R Sprengel
Affiliations

Conditional restoration of hippocampal synaptic potentiation in Glur-A-deficient mice

V Mack et al. Science. .

Abstract

Plasticity of mature hippocampal CA1 synapses is dependent on l-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors containing the glutamate receptor A (GluR-A) subunit. In GluR-A-deficient mice, plasticity could be restored by controlled expression of green fluorescent protein (GFP)-tagged GluR-A, which contributes to channel formation and displayed the developmental redistribution of AMPA receptors in CA1 pyramidal neurons. Long-term potentiation (LTP) induced by pairing or tetanic stimulation was rescued in adult GluR-A(-/-) mice when (GFP)GluR-A expression was constitutive or induced in already fully developed pyramidal cells. This shows that GluR-A-independent forms of synaptic plasticity can mediate the establishment of mature hippocampal circuits that are prebuilt to express GluR-A-dependent LTP.

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