Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 2001 May;49(5):273-8.
doi: 10.1007/BF02913132.

Effect of tranexamic acid on blood loss reduction after cardiopulmonary bypass

Y Uozaki  1 , G Watanabe, K Kotou, K Ueyama, Y Doi, T Misaki
Affiliations
Clinical Trial

Effect of tranexamic acid on blood loss reduction after cardiopulmonary bypass

Y Uozaki et al. Jpn J Thorac Cardiovasc Surg. 2001 May.

Abstract

Objective: We evaluated the effect of tranexamic acid on blood loss in patients undergoing elective cardiopulmonary bypass for coronary artery bypass surgery.

Methods: We randomly assigned 7 of 14 patients to a group receiving 50 mg/kg tranexamic acid before skin incision and after the start of cardiopulmonary bypass and the other 7 as controls.

Results: Intraoperative and postoperative blood loss was significantly (p = 0.025) reduced in the tranexamic acid group. A similar decrease in platelet count was observed during cardiopulmonary bypass in both groups. Antithrombin III was significantly (p = 0.013) decreased in both groups during cardiopulmonary bypass. Antithrombin III and thrombin-antithrombin III complexes were significantly (p = 0.001) increased after protamine administration. A significant (p = 0.010) decrease in alpha 2-plasmin inhibitor was noted at 5 and 60 minutes after the start of cardiopulmonary bypass in the tranexamic acid group. alpha 2-plasmin inhibitor-plasmin complexes were significantly (p = 0.001) increased after the start of cardiopulmonary bypass in both groups and were significantly (p = 0.012) decreased after protamine administration. alpha 2-plasmin inhibitor-plasmin complexes in the tranexamic acid group were significantly (p = 0.030) lower than in controls 60 minutes after the start of cardiopulmonary bypass, just prior to the end of cardiopulmonary bypass, and after protamine administration.

Conclusions: These findings showed that tranexamic acid administration effectively prevented perioperative blood loss without thromboembolic complications and that tranexamic acid during cardiopulmonary bypass coordinates the anticoagulative effect of heparin and the antifibrinolytic effect of tranexamic acid.

PubMed Disclaimer

References

    1. J Thorac Cardiovasc Surg. 1990 Jan;99(1):70-4 - PubMed
    1. Ann Thorac Surg. 1989 Oct;48(4):536-9 - PubMed
    1. J Thorac Cardiovasc Surg. 1994 Jul;108(1):99-106; discussion 106-8 - PubMed
    1. Can J Surg. 1967 Jul;10(3):304-7 - PubMed
    1. Semin Thromb Hemost. 1985 Jul;11(3):281-92 - PubMed

Publication types