Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1975;287(4):391-7.
doi: 10.1007/BF00500040.

Absence of muscarinic modulation of vasopressin release from the isolated rat neurophypophysis

Absence of muscarinic modulation of vasopressin release from the isolated rat neurophypophysis

H Kilbinger et al. Naunyn Schmiedebergs Arch Pharmacol. 1975.

Abstract

1. Isolated rat neurohypophyses were incubated in Locke solution at 37 degress C and the vasopressin output into the medium determined by bioassay. 2. Potassium chloride 60 mM caused a 9-fold increase in the rate of vasopressin release that was abolished when calcium chloride was omitted from the Locke solution. 3. Acetylcholine 5.5x10-4M neither alone nor in the presence of atropine 2.9x10-6M changed the "resting" release of vasopressin. 4. Neither acetylcholine 5.5x10-4M oxotremorine 10-4 and k3x10-4M altered the vasopressin release evoked by potassium chloride 60 mM. 5. In contrast to the peripheral adrenergic nerve fibres, the secretory terminal fibres of the neurohypophysis do not appear to contain muscarinic inhibitory or nicotinic excitatory receptors.

PubMed Disclaimer

References

    1. J Physiol. 1961 Nov;159:40-57 - PubMed
    1. Am J Physiol. 1972 Aug;223(2):310-8 - PubMed
    1. Prog Brain Res. 1973;39:21-39 - PubMed
    1. J Physiol. 1966 Jul;185(2):429-44 - PubMed
    1. J Physiol. 1964 Jul;172:1-18 - PubMed