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. 2001 Jul 15;98(2):428-35.
doi: 10.1182/blood.v98.2.428.

Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration

K Podar  1 , Y T Tai, F E Davies, S Lentzsch, M Sattler, T Hideshima, B K Lin, D Gupta, Y Shima, D Chauhan, C Mitsiades, N Raje, P Richardson, K C Anderson
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Free article

Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration

K Podar et al. Blood. .
Free article

Abstract

Multiple myeloma (MM) remains incurable, with a median survival of 3 to 4 years. This study shows direct effects of vascular endothelial growth factor (VEGF) upon MM and plasma cell leukemia (PCL) cells. The results indicate that VEGF triggers tumor cell proliferation via a protein kinase C (PKC)-independent Raf-1-MEK-extracellular signal-regulated protein kinase pathway, and migration via a PKC-dependent pathway. These observations provide the framework for novel therapeutic strategies targeting VEGF signaling cascades in MM.

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