Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2001 Jul 6;85(1):98-101.
doi: 10.1054/bjoc.2001.1857.

Tcf-3 expression and beta-catenin mediated transcriptional activation in aggressive fibromatosis (desmoid tumour)

S Tejpar  1 , C Li, C Yu, R Poon, H Denys, R Sciot, E Van Cutsem, J J Cassiman, B A Alman
Affiliations
Free PMC article

Tcf-3 expression and beta-catenin mediated transcriptional activation in aggressive fibromatosis (desmoid tumour)

S Tejpar et al. Br J Cancer. .
Free PMC article

Abstract

Aggressive fibromatosis harbours mutations resulting in beta-catenin protein stabilization. Primary cell cultures demonstrate constitutive tcf activation in aggressive fibromatosis. Expression and co-immunoprecipitation studies suggest that beta-catenin binds and activates tcf-3 in this tumour. This is the first demonstration of tcf-3 activation by beta-catenin stabilization in a human neoplastic process.

PubMed Disclaimer

References

    1. Mol Cell Biol. 1996 Aug;16(8):4088-94 - PubMed
    1. Genes Dev. 1995 Mar 15;9(6):700-13 - PubMed
    1. Science. 1997 Mar 21;275(5307):1784-7 - PubMed
    1. Science. 1997 Mar 21;275(5307):1787-90 - PubMed
    1. Diagn Mol Pathol. 1997 Apr;6(2):98-101 - PubMed

Publication types