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Clinical Trial
. 2001 Aug 1;33(3):409-11.
doi: 10.1086/321864. Epub 2001 Jun 21.

Efficacy and safety of clarithromycin as treatment for Mediterranean spotted fever in children: a randomized controlled trial

A Cascio  1 , C Colomba, D Di Rosa, L Salsa, L di Martino, L Titone
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Free article
Clinical Trial

Efficacy and safety of clarithromycin as treatment for Mediterranean spotted fever in children: a randomized controlled trial

A Cascio et al. Clin Infect Dis. .
Free article

Erratum in

  • Clin Infect Dis 2001 Sep 1;33(5):749

Abstract

Fifty-one children with Mediterranean spotted fever (MSF) were randomized to receive either clarithromycin, 15 mg/kg/day orally in 2 divided doses, or chloramphenicol, 50 mg/kg/day orally in 4 divided doses, for 7 days. Mean time to defervescence was 36.7 h in the clarithromycin group and 47.1 h in the chloramphenicol group (P=.047). Clarithromycin could be an acceptable therapeutic alternative to chloramphenicol and to tetracyclines for children aged <8 years with MSF.

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