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Review
. 2001 Jun:16:106-9.
doi: 10.1152/physiologyonline.2001.16.3.106.

Polyamines: new cues in cellular signal transduction

U Bachrach  1 , Y C Wang, A Tabib
Affiliations
Review

Polyamines: new cues in cellular signal transduction

U Bachrach et al. News Physiol Sci. 2001 Jun.

Abstract

The naturally occurring polyamines putrescine, spermidine, and spermine are involved in signal transduction. This has been demonstrated by using inhibitors for polyamine biosynthesis (such as alpha-difluoromethylornithine) or adding polyamines to cultured cells. Different polyamines, preferentially activated protein kinases (tyrosine kinases and MAP kinases), stimulated the expression of nuclear protooncogenes (myc, jun, and fos).

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