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. 2001 Jul;12(7):853-62.
doi: 10.1016/S1044-0305(01)00264-1.

Electrochemical processes in a wire-in-a-capillary bulk-loaded, nano-electrospray emitter

G J Van Berkel  1 , K G Asano, P D Schnier
Affiliations
Free article

Electrochemical processes in a wire-in-a-capillary bulk-loaded, nano-electrospray emitter

G J Van Berkel et al. J Am Soc Mass Spectrom. 2001 Jul.
Free article

Abstract

Experiments are described that illustrate solvent oxidation, emitter electrode corrosion, and analyte oxidation in positive ion mode nano-electrospray mass spectrometry using a wire-in-a-capillary, bulk-loaded nano-electrospray emitter geometry. Time-lapsed color photography of pH and metal specific indicator solutions within operating nano-electrospray emitters, as well as temporal changes in the ions observed in the nano-electrospray mass spectra, are used to probe these reactions, judge their magnitude, and study the time dependent changes in solution composition and gas-phase ion signal brought about as a result of these electrochemical reactions. The significance of these observations for analytical applications of nano-electrospray mass spectrometry are discussed.

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References

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