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Case Reports
. 2001 Jul 10;57(1):127-30.
doi: 10.1212/wnl.57.1.127.

Intention tremor, parkinsonism, and generalized brain atrophy in male carriers of fragile X

R J Hagerman  1 , M Leehey, W Heinrichs, F Tassone, R Wilson, J Hills, J Grigsby, B Gage, P J Hagerman
Affiliations
Case Reports

Intention tremor, parkinsonism, and generalized brain atrophy in male carriers of fragile X

R J Hagerman et al. Neurology. .

Abstract

The authors report five elderly men with the fragile X premutation who had a progressive action tremor associated with executive function deficits and generalized brain atrophy. These individuals had elevated fragile X mental retardation 1 gene (FMR1) messenger RNA and normal or borderline levels of FMR1 protein. The authors propose that elevations of FMR1 messenger RNA may be causative for a neurodegenerative syndrome in a subgroup of elderly men with the FMR1 premutation.

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