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Case Reports
. 2001 Jun;40(6):536-40.
doi: 10.2169/internalmedicine.40.536.

Malignant fibrous histiocytoma of soft tissue producing granulocyte colony-stimulating factor

E Mayumi  1 , T Okuno, T Ogawa, K Kurata, H Ishioka, H Hamamoto, K Ishiki, T Maga, T Okamoto, T Yoshida, Y Ogura
Affiliations
Free article
Case Reports

Malignant fibrous histiocytoma of soft tissue producing granulocyte colony-stimulating factor

E Mayumi et al. Intern Med. 2001 Jun.
Free article

Abstract

We treated a rare case of malignant fibrous histiocytoma (MFH) of soft tissue that produced granulocyte colony-stimulating factor (G-CSF). The patient, an 80-year-old woman, was admitted because of a feeling of abdominal fullness and leg edema. An elastic, hard, tender tumor was palpated in the right thigh. Histopathological examinations of the tumor revealed atypical and prominent pleomorphic spindle-shaped cells with funicular arrangement, which were compatible with the diagnosis of MFH. Prominent leukocytosis (up to 84,300/microl), a high serum G-CSF concentration (82 pg/ml) and positive immunohistochemical staining of the tumor tissue for G-CSF indicated that G-CSF was produced by the MFH.

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