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Comparative Study
. 1975;11(4):289-94.
doi: 10.1007/BF01326751.

Action of tetrodotoxin on the contractile responses of isolated guinea-pig urinary bladder preparation to x-irradiation and to electrical stimulation

M C Michailov, U E Welscher, C M Wolffhardt
Comparative Study

Action of tetrodotoxin on the contractile responses of isolated guinea-pig urinary bladder preparation to x-irradiation and to electrical stimulation

M C Michailov et al. Radiat Environ Biophys. 1975.

Abstract

Tetrodotoxin (10- minus 8 to 10- minus 6 g/ml) blocked the contractile responses of isolated guinea-pig urinary bladder preparation to electrical (25 and 100 Hz) neural but not to transmural stimulation and to X-irradiation (50 kV, 20 kR/min, 20 kR). The irradiation had no influence on the bladder responses to electrical and hormonal (acetylcholine and histamine) stimulation. It is concluded that the X-ray-induced contraction is of myogenic origin and that it is possibly not related to the electro-mechanical coupling system.

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