Review
doi: 10.1006/pupt.2001.0285.
Protease-activated receptor-2 (PAR2) in the airways
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- PMID: 11448145
- DOI: 10.1006/pupt.2001.0285
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Review
Protease-activated receptor-2 (PAR2) in the airways
Pulm Pharmacol Ther.
2001.
Abstract
Protease-activated receptors (PARs) act as sensors for active extracellular serine proteases. Since serine proteases like mast cell tryptase are associated with inflammatory processes, PARs may represent novel pharmacological targets in airway diseases like asthma and chronic obstructive pulmonary disease. However, our present understanding of the physiological roles of PARs is in its infancy. In this review we highlight evidence for the involvement of PARs in airway disease and propose that these novel receptors may play mainly protective roles.
Copyright Academic Press.
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